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DRF: Thesis subject SL-DRF-20-0532

RESEARCH FIELD
Chemistry / Condensed matter physics, chemistry & nanosciences
TITLE English Français

Functionnalized nanoparticles for radiosensitization

ABSTRACT

This project involves the development of new delivery systems for drugs based on the degradation of polymers by irradiation. This new stimulus has never been explored for such applications. This permits to consider a coupled chemo- and radiotherapy beyond the simple trigger release. The objective is to perform the synthesis of a library of original amphiphilic copolymers, i.e. with a water-soluble/biocompatible part, together with a hydrophobic/radiosensitive part. The self-assembly into micelles or vesicles will lead to objects with a radiosensitive core where the drug will be located. The first advantage of these new systems is to control more finely the targeting of drug to the tumor cells and to avoid the side effects associated with chemotherapy and radiotherapy, by controlling the position of the irradiating beam and/or the absorbed doses.

LOCATION
Institut rayonnement et matière de Saclay
Service Nanosciences et Innovation pour les Materiaux, la Biomédecine et l’Energie
Laboratoire Innovation, Chimie des Surfaces Et Nanosciences
Place: Saclay
Start date of the thesis: 01/10/2017
CONTACT PERSON

Geraldine CARROT  

CEA
DRF/IRAMIS/NIMBE/LICSEN
Bat 466
CEA/Saclay

Phone number: +33 1 69 08 41 47

UNIVERSITY / GRADUATE SCHOOL
Paris-Saclay
Sciences Chimiques: Molécules, Matériaux, Instrumentation et Biosystèmes (2MIB)
THESIS SUPERVISOR

Jean-Philippe RENAULT

CEA
DRF/IRAMIS/NIMBE/LIONS
IRAMIS/NIMBE/LIONS
CEA/Saclay
Bat. 546
91191 Gif/Yvette