DRF : Sujet de thèse SL-DRF-18-0986
Développement de la RMN par DNP (polarisation dynamique nuléaire) pour l'étude de glycopolymères
INAC (Institute for Nanoscience and Cryogenics, CEA Grenoble) has a PhD opening for a physical chemist. The PhD will deal with the development and application of a new and emerging hyperpolarization technique: high-magnetic field MAS-DNP (Magic Angle Spinning Dynamic Nuclear Polarization). This approach is used to hyperpolarize nuclei such that high-sensitivity and high-resolution solid-state NMR (Nuclear Magnetic Resonance) spectra can be obtained and used to extract important structural information at the atomic scale, such as surface functionalization and internuclear proximities/distances, as well as crystallographic data, etc.
Since the potential of this technique is beginning to be realized, the aim of this PhD is to further develop the methodology (sample preparation, new polarizing agents and radio-frequency pulse schemes) for the study of complex glycopolymers. This will be achieved through the combined use of EPR, DNP and MAS-DNP numerical simulation as well as developing advanced NMR experiments.
The thesis will mainly be performed in the DNP group of the Institute for Nanosciences and Cryogenics (CEA/University Grenoble Alpes) (http://www.dnpgrenoble.net/) in the context of international and industrial collaborations (NHMFL Tallahassee, Florida and Bruker Biospin). It will take place in a highly dynamical environment at the MINATEC campus (CEA Grenoble) within the MEM laboratory (CEA INAC) where the DNP group, in collaboration with the Bruker company (world leader in NMR instrumentation), is currently pushing the development and use of this technique (high magnetic field DNP) far beyond its state-of-the-art. The group has two high-field MAS-DNP systems and has successfully conducted instrumental and methodological developments in the subsequent years. Notably, the group has built equipment that can sustainably cool large flows of Helium gas and thus consequently has access to MAS-DNP performed at very low temperatures (10-100 K), which opens a whole realm of experimental possibilities.
This PhD work will take place within a larger ERC-funded project (PI G. De Paëpe) involving strong partnerships between academic laboratories and industrial partners.
Master en chimie-physique
Modélisation et Exploration des Matériaux
Laboratoire de Résonance Magnétique
Centre : Grenoble
Date souhaitée pour le début de la thèse : 01/10/2018
Chimie et Sciences du Vivant (EDCSV)
Gaël DE PAEPE
17 rue des Martyrs
38054 Grenoble cedex 9