CEA INSTN - Theses by Direction - Life Sciences Thèses proposées par le CEA INSTN Wed, 19 Jun 2013 17:02:27 +0200 http://www-instn.cea.fr/ <![CDATA[Statistical analysis of RNA interference functional screen on cancer cells - Joint PhD between the Finnish VTT and the French CEA]]> laurent.guyon@cea.fr (Laurent GUYON) Wed, 01 May 2013 12:00:00 +0200 <![CDATA[Chromatin dynamics for fine-tuned activation of flower development genes]]> Christel.carles@ujf-grenoble.fr (Christel CARLES) Tue, 01 Oct 2013 12:00:00 +0200 <![CDATA[Characterisation of mechanisms of vaccine induced immune responses through skin targeting strategies]]> roger.le-grand@cea.fr (Roger LE GRAND) Sat, 01 Dec 2012 12:00:00 +0100 <![CDATA[The effect of microenvironment on tubulogenesis in prostate epithelium. The advantages of 3D cell culture and lens-free imaging.]]> nathalie.picollet-dhahan@cea.fr (Nathalie PICOLLET-D'HAHAN) Tue, 01 Oct 2013 12:00:00 +0200 <![CDATA[Role of HLA-G in B cell response: implications in transplantation]]> Nathalie.Rouas-Freiss@cea.fr (Nathalie ROUAS-FREISS) Tue, 01 Oct 2013 12:00:00 +0200 <![CDATA[Structure-based prediction of protein interactions at the genome scale]]> guerois@cea.fr (Raphael GUEROIS) Tue, 01 Oct 2013 12:00:00 +0200 <![CDATA[Functional characterization of a novel histone variant implicated in the senescence of human cells induced by persistent DNA damage, and its potiential role as a stress biomarker during aging]]> carl.mann@cea.fr (Carl MANN) Sun, 01 Sep 2013 12:00:00 +0200 <![CDATA[Polymerized micelles for the diagnosis and therapy of tumors]]> eric.doris@cea.fr (Eric DORIS) Mon, 01 Oct 2012 12:00:00 +0200 <![CDATA[Alternative mechanisms of telomere maintenance and radiation resitance of glioma stem cells]]> boussin@cea.fr (François BOUSSIN) <![CDATA[The origine of resistance to genotoxic stress at low doses of leukemic mature and immature progenitor cells]]> jozo.delic@cea.fr (Jozo DELIC) Tue, 01 Oct 2013 12:00:00 +0200 <![CDATA[High-throughput screening to discover genes to convert plant biomass to fuels and chemicals]]> atolonen@genoscope.cns.fr (Andrew Tolonen) Fri, 01 Nov 2013 12:00:00 +0100 <![CDATA[Role of the Sonic Hedeghog pathway in individual sensitivity to radiation]]> michele.martin@cea.fr (Michèle MARTIN) Sun, 01 Sep 2013 12:00:00 +0200 <![CDATA[ Identification of genes regulating the early events of oxidative lesions recognition by OGG1. ]]> anna.campalans@cea.fr (Anna CAMPALANS) Tue, 01 Oct 2013 12:00:00 +0200 <![CDATA[Nuclear architecture modulation and senescence induction mechanisms]]> pascale.bertrand@cea.fr (Pascale BERTRAND) Sun, 01 Sep 2013 12:00:00 +0200 <![CDATA[Genome-wide integrated analysis of radiation induced epigenetic alterations ]]> tost@cng.fr (Jorg TOST) Sun, 01 Sep 2013 12:00:00 +0200 <![CDATA[Clickable chelates for imaging applications]]> frederic.taran@cea.fr (Frédéric TARAN) Sun, 01 Sep 2013 12:00:00 +0200 <![CDATA[Role of the pilin RrgA adhesin of Streptococcus pneumoniae in human tissues colonization]]> anne-marie.di-guilmi@ibs.fr (Anne Marie DI GUILMI) Tue, 01 Oct 2013 12:00:00 +0200 <![CDATA[Interest of the gene expression information -level and localization- provided by the Allen Atlas in the analysis of imaging-genetics data in humans]]> edouard.duchesnay@cea.fr (Edouard DUCHESNAY) Tue, 01 Oct 2013 12:00:00 +0200 <![CDATA[Multi-scale anatomical and intrinsic functional brain connectivity]]> marc.joliot@cea.fr (Marc JOLIOT) Sun, 01 Sep 2013 12:00:00 +0200 <![CDATA[Origin, nature and role in vaginal transmission of HIV/SIV infected cells in semen: from basic science to prevention strategies’ proof of concept]]> roger.le-grand@cea.fr (Roger LE GRAND) Sat, 01 Jun 2013 12:00:00 +0200 <![CDATA[Dynamics of innate and memory responses after MVA immunization: prime/boost strategies optimization]]> frederic.martinon@cea.fr (Frédéric MARTINON) Sat, 01 Jun 2013 12:00:00 +0200 <![CDATA[Skin radiation decontamination: efficacy and mechanisms of action of decontamination products]]> nina.griffiths@cea.fr (Nina Griffiths) Tue, 01 Oct 2013 12:00:00 +0200 <![CDATA[Study of eukaryotic spatio-temporal program of replication]]> arach.goldar@cea.fr (Arach Goldar) Tue, 01 Oct 2013 12:00:00 +0200 <![CDATA[Molecular mechanisms of multispecificity of recognition and active transmembrane transport by P-glycoprotein]]> stephane.orlowski@cea.fr (Stéphane ORLOWSKI) Tue, 01 Oct 2013 12:00:00 +0200 <![CDATA[Structural studies of double strand break repair macromolecular assemblies: Contribution to diagnosis of severe immunodeficiencies]]> jb.charbonnier@cea.fr (Jean-Baptiste CHARBONNIER) Sun, 01 Sep 2013 12:00:00 +0200 <![CDATA[Intracellular dynamics of ion transport in plants using real-time imaging approaches]]> helene.javot@cea.fr (Hélène JAVOT) Tue, 01 Oct 2013 12:00:00 +0200 <![CDATA[Pre-clinical study of the functional aspects of the neurovascular unit using PET imaging during acute exposure to tobacco smoke]]> nicolas.tournier@cea.fr (Nicolas TOURNIER) Sat, 01 Jun 2013 12:00:00 +0200 <![CDATA[Non-targeted effects of ionizing radiation: implication of cancer stem cells and epithelial-mesenchymal transition in long-term genetic instability]]> jerome.lebeau@cea.fr (Jérôme LEBEAU) Sun, 01 Sep 2013 12:00:00 +0200 <![CDATA[Structural and functional studies the bacterial GTPase EngA to identify new antibiotic compounds]]> jean-michel.jault@ibs.fr (Jean-Michel JAULT) Tue, 01 Oct 2013 12:00:00 +0200 <![CDATA[Molecular basis study of the balance regulation between differentiation and prolifération in the control of stem cell and progeniteur expansion]]> stany.chretien@cea.fr (Stany CHRETIEN) Sun, 01 Sep 2013 12:00:00 +0200 <![CDATA[Membrane protein: from NMR structural and dynamical characterisation towards function]]> paul.schanda@ibs.fr (Paul SCHANDA) Tue, 01 Oct 2013 12:00:00 +0200 <![CDATA[Combining high field MRI with biological superparamagnetic contrast agents for molecular imaging of brain diseases]]> sebastien.meriaux@cea.fr (Sébastien Mériaux) Tue, 01 Oct 2013 12:00:00 +0200 <![CDATA[Identification of new genes implicated in coenzyme Q biosynthesis]]> fabien.pierrel@cea.fr (Fabien PIERREL) Tue, 01 Oct 2013 12:00:00 +0200 <![CDATA[Genetic engineering of magnetotactic bacteria for cobalt bioremediation]]> monique.sabaty@cea.fr (Monique SABATY) Sun, 01 Sep 2013 12:00:00 +0200 <![CDATA[Role of a P4 ATPase in the membrane glycerolipid homeostasis of Arabidopsis thaliana.]]> juliette.jouhet@cea.fr (Juliette JOUHET) Tue, 01 Oct 2013 12:00:00 +0200 <![CDATA[Crystallographic studies of FNR (the regulator of Fumarate and Nitrate Reduction) and its regulation by molecular oxygen]]> yvain.nicolet@ibs.fr (Yvain NICOLET) Tue, 01 Oct 2013 12:00:00 +0200 <![CDATA[Development by rational design of tools suitable for the detection of protein-protein interactions in vivo]]> royant@ibs.fr (Antoine ROYANT) Tue, 01 Oct 2013 12:00:00 +0200 <![CDATA[Methodological developments in phosphorus-31 and oxygen-17 NMR to study brain metabolism during neurodegenerative processes in vivo]]> julien.valette@cea.fr (Julien Valette) Sun, 01 Sep 2013 12:00:00 +0200 <![CDATA[Toxicity mechanisms of LRRK2 mutations in Parkinson's disease]]> emmanuel.brouillet@cea.fr (Emmanuel BROUILLET) Mon, 01 Oct 2012 12:00:00 +0200 <![CDATA[Inhibitors of proteasomes c and i, against cancer or inflammatory and autoimmune diseases]]> daniel.gillet@cea.fr (Daniel GILLET) Tue, 01 Oct 2013 12:00:00 +0200 <![CDATA[Functional and structural study of Llp, the immunity protein of Phage T5]]> cecile.breyton@ibs.fr (Cécile BREYTON) Sun, 01 Sep 2013 12:00:00 +0200 <![CDATA[Dynamical study of large size protein assembly by nuclear relaxation of the methyl groups.]]> dominique.marion@ibs.fr (Dominique MARION) Tue, 01 Oct 2013 12:00:00 +0200 <![CDATA[Periplasmic chaperones and envelope stress. Structural and functional characterization of ZraP]]> eve.derosny@ibs.fr (Eve de Rosny) Sun, 01 Sep 2013 12:00:00 +0200 <![CDATA[Identification of a novel intracellular proteolytic machine]]> franzetti@ibs.fr (Bruno FRANZETTI) Tue, 01 Oct 2013 12:00:00 +0200 <![CDATA[Quantitative MRI at Ultra High Field: toward a fast and reliable T1, T2 and Proton Density mapping on human at 7T and 11.7T]]> alexandre.vignaud@cea.fr (Alexandre Vignaud) Sun, 01 Sep 2013 12:00:00 +0200 <![CDATA[Inferences of of regulatory networks through analysis of HTS data coupled to metabolic networks: application to the genome of the model bacterium Acinetobacter baylyi.]]> scruveil@genoscope.cns.fr (Stéphane CRUVEILLER) Tue, 01 Jan 2013 12:00:00 +0100 <![CDATA[Mechanisms in viral dissemination and persistence in arthralgia inducing alphaviruses: comparison of Chikungunya, Ross River and Mayaro virus in vitro and in animal models]]> pierre.roques@cea.fr (Pierre ROQUES) <![CDATA[Crystallization with an automated microfluidic pipeline: from crystal screening to crystal mounting]]> jean-luc.ferrer@ibs.fr (Jean-Luc FERRER) Tue, 01 Oct 2013 12:00:00 +0200 <![CDATA[Structural and functional analysis of HSulf enzymes]]> romain.vives@ibs.fr (Romain VIVES) Tue, 01 Oct 2013 12:00:00 +0200 <![CDATA[Inhibition and structural characterization of HIV uptake mechanism mediated by CLRs]]> franck.fieschi@ibs.fr (Franck FIESCHI) Tue, 01 Oct 2013 12:00:00 +0200 <![CDATA[Nuclear export of the HIV-1 Rev ribonucleoprotein particle]]> carlo.petosa@ibs.fr (Carlo PETOSA) Sun, 01 Sep 2013 12:00:00 +0200 <![CDATA[Imaging of glioma and glioma-associated inflammation using TSPO radioligands]]> alexandra.winkeler@cea.fr (Alexandra Winkeler) Sat, 01 Jun 2013 12:00:00 +0200 <![CDATA[Development of a tauopathy model in rodents]]> karine.cambon@cea.fr (karine cambon) Mon, 01 Oct 2012 12:00:00 +0200 <![CDATA[Conception of new phototransformable sensors for advanced fluorescence microscopy]]> dominique.bourgeois@ibs.fr (Dominique BOURGEOIS) Tue, 01 Oct 2013 12:00:00 +0200 <![CDATA[Study of HLA class I expression modulation and its consequences on the innate immune response during the early stages of SIV / HIV infection ]]> benoit.favier@cea.fr (Benoit FAVIER) Tue, 01 Oct 2013 12:00:00 +0200 <![CDATA[Gene therapy for Huntington's disease by trans-splicing of the IT15 mRNA]]> alexis.bemelmans@cea.fr (Alexis BEMELMANS) Sun, 01 Sep 2013 12:00:00 +0200 <![CDATA[Proteomic exploration of Pseudomonas aeruginosa membrane macrocomplexes : assembly and regulation]]> iattreedelic@cea.fr (Ina ATTREE) Tue, 01 Oct 2013 12:00:00 +0200 <![CDATA[Quantitative analysis of histological sections acquired by virtual microscopy: from cellular to whole brain analysis]]> thierry.delzescaux@cea.fr (Thierry DELZESCAUX) Tue, 01 Oct 2013 12:00:00 +0200 <![CDATA[ Engineering cyanobacteria for high-level photoproduction of biofuels]]> franck.chauvat@cea.fr (Franck CHAUVAT) Tue, 01 Oct 2013 12:00:00 +0200 <![CDATA[ Lab on Chip technologies to develop high throughput and ultrasensitive diagnostic tests ]]> vincent.dive@cea.fr (Vincent DIVE) Sun, 01 Sep 2013 12:00:00 +0200 <![CDATA[Structure-function studies of the type III secretion systems of major human pathogens]]> dessen@ibs.fr (Andréa DESSEN) Sun, 01 Sep 2013 12:00:00 +0200 <![CDATA[Molecular mechanisms of uranium tolerance in Microbacterium]]> virginie.chapon@cea.fr (Virginie CHAPON) Sun, 01 Sep 2013 12:00:00 +0200 <![CDATA[Development of new enzymatic catalysts via in vivo directed evolution]]> mbouzon@genoscope.cns.fr (Madeleine Bouzon Bloch) Tue, 01 Oct 2013 12:00:00 +0200 <![CDATA[Oxidative stress production (ROS and RNS) linked to metallopeptides and metalloproteins involved in neurodegeneration]]> pierre.dorlet@cea.fr (Pierre DORLET) Mon, 01 Oct 2012 12:00:00 +0200 <![CDATA[Characterization of cortical structural connectivity in adults: Modulation by sex, handedness and cognitive abilities.]]> fabrice.crivello@u-bordeaux2.fr (Fabrice CRIVELLO) Tue, 01 Oct 2013 12:00:00 +0200 <![CDATA[Tritium-labelled nanodiamond : from incorporation mecanisms to in vivo applications]]> bernard.rousseau@cea.fr (Bernard ROUSSEAU) Fri, 01 Mar 2013 12:00:00 +0100 <![CDATA[DNA replication in eukaryotic cells : Relation between chromatin conformation and kinetic of DNA replication ]]> arach.goldar@cea.fr (Arach Goldar) Tue, 01 Oct 2013 12:00:00 +0200 <![CDATA[Molecular modeling studies of Coupled Electron Transfer Processes in Proteins]]> martin.field@ibs.fr (Martin FIELD) Sun, 01 Sep 2013 12:00:00 +0200 <![CDATA[Biochemical mechanisms involved in bone resorption as a consequence of uranyl accumulation in bones. ]]> claude.vidaud@cea.fr (Claude VIDAUD) Sun, 01 Sep 2013 12:00:00 +0200 <![CDATA[Regulation of endocytic trafficking: roles of arrestin-related proteins]]> laubry@cea.fr (Laurence AUBRY) Sun, 01 Sep 2013 12:00:00 +0200 <![CDATA[Characterization of the glycerolipid metabolism, subcellular compartmentalization and control in the diatom Phaeodactylum tricornutum]]> eric.marechal@cea.fr (Eric MARECHAL) Tue, 01 Oct 2013 12:00:00 +0200 <![CDATA[Signaling of cell cycle entry of quiescent neural stem cells]]> marc-andre.mouthon@cea.fr (Marc-André MOUTHON) Tue, 01 Oct 2013 12:00:00 +0200 <![CDATA[Structural and Functional Studies of Tumor Suppressor Genes involved in Mismatch Repair DNA pathway]]> jb.charbonnier@cea.fr (Jean-Baptiste CHARBONNIER) Sun, 01 Sep 2013 12:00:00 +0200 <![CDATA[analysis using yeast system of tubulin mutation associated to mental disability]]> cecile.boscheron@cea.fr (Cécile BOSCHERON) Tue, 01 Oct 2013 12:00:00 +0200 <![CDATA[Mechanism of assembly of an actin contractile ring]]> laurent.blanchoin@cea.fr (Laurent BLANCHOIN) Tue, 01 Oct 2013 12:00:00 +0200 <![CDATA[Development of a new animal model of Alzheimer's disease: Multidisciplinary evaluation by histology, biochemistry, PET and MRI imaging and therapeutic approaches]]> Marc.Dhenain@cea.fr (Marc DHENAIN) Sun, 01 Sep 2013 12:00:00 +0200 <![CDATA[OXYGEN ACTIVATION BY THE BIOPTERIN COFACTOR IN NO-SYNTHASES]]> pierre.dorlet@cea.fr (Pierre DORLET) Tue, 01 Oct 2013 12:00:00 +0200 <![CDATA[Assessment of Effects Induced by Nano-TiO2 on Adult and Ageing Brains]]> aloise.mabondzo@cea.fr (Aloïse MABONDZO) Fri, 01 Feb 2013 12:00:00 +0100 <![CDATA[Functions of CYLD deubiquitinase and dysfunction in pathology]]> marie-odile.fauvarque@cea.fr (Marie-Odile FAUVARQUE) Tue, 01 Oct 2013 12:00:00 +0200 <![CDATA[NOS-LPs: multifunctional caracterisation of a new enzyme family]]> jerome.santolini@cea.fr (Jérôme SANTOLINI) Tue, 01 Oct 2013 12:00:00 +0200 <![CDATA[Relationships between cell division and triglyceride metabolism in plants and algae]]> frebeille@cea.fr (Fabrice RÉBEILLÉ) Sun, 01 Sep 2013 12:00:00 +0200 <![CDATA[Development and characterization of new photocatalysts for CO2 reduction]]> annamaria.quaranta@cea.fr (Annamaria QUARANTA) Tue, 01 Oct 2013 12:00:00 +0200 <![CDATA[Cellular and Animal Models of the Alzheimer's Disease and related Diseases: Characterization by Omic and of Molecular Imaging Approaches]]> aloise.mabondzo@cea.fr (Aloïse MABONDZO) Sun, 01 Sep 2013 12:00:00 +0200 <![CDATA[Antibody-Drug conjugates targeting the glioblastoma cancer stem cells.]]> didier.boquet@cea.fr (Didier BOQUET) Tue, 01 Oct 2013 12:00:00 +0200 <![CDATA[Role of reactive oxygen species in seed germination and longevity]]> anja.krieger-liszkay@cea.fr (Anja KRIEGER-LISZKAY) Tue, 01 Oct 2013 12:00:00 +0200 <![CDATA[Role of Mlh1 and its partners in homologous recombination during meiosis]]> emmanuelle.martini@cea.fr (Emmanuelle MARTINI) Sun, 01 Sep 2013 12:00:00 +0200 <![CDATA[Chiral building block synthesis by enzymatic cascade reactions]]> azaparuc@genoscope.cns.fr (Anne ZAPARUCHA) Tue, 01 Oct 2013 12:00:00 +0200 <![CDATA[Evaluation of the vaccinating effect of enteropathogenic type III secretion system proteins]]> stephanie.simon@cea.fr (Stéphanie SIMON) Tue, 01 Oct 2013 12:00:00 +0200 <![CDATA[New probe for the detection of the superoxide radical in vivo. Superoxide reductase – green fluorescent protein fusion.]]> vniviere@cea.fr (Vincent NIVIÈRE) Tue, 01 Oct 2013 12:00:00 +0200 <![CDATA[Fanconi anemia and germinal lineage]]> pierre.fouchet@cea.fr (Pierre FOUCHET) Tue, 01 Oct 2013 12:00:00 +0200 <![CDATA[Functional study of the role of the plant transcription factor LFY in the acquirement of the meristematic identity of floral primordial ]]> gabrielle.tichtinsky@ujf-grenoble.fr (Gabrielle Tichtinsky) Tue, 01 Oct 2013 12:00:00 +0200 <![CDATA[New genomic approaches for association studies.]]> artigue@genoscope.cns.fr (François ARTIGUENAVE) Tue, 01 Oct 2013 12:00:00 +0200 <![CDATA[Functional approach of adrenocortical tumorigenesis in an animal model and development of innovative therapies]]> Michael.Thomas@cea.fr (Michael THOMAS) Tue, 01 Oct 2013 12:00:00 +0200 <![CDATA[Molecular mechanisms of radiation-induced migration of normal neural stem cells and glioma stem cells]]> laurent-r.gauthier@cea.fr (Laurent GAUTHIER) Sun, 01 Sep 2013 12:00:00 +0200 <![CDATA[HLA-G expression by induced Pluripotent Stem Cells (iPS) and development of a strategy to obtain HLA-G-expressing differentiated cells/tissues for regenerative medicine ]]> Joel.LeMaoult@cea.fr (Joel LEMAOULT) Sun, 01 Sep 2013 12:00:00 +0200 <![CDATA[TIF1g a major actor in inflammation : functional studies in mouse and human]]> paul-henri.romeo@cea.fr (Paul-Henri ROMEO) Sun, 01 Sep 2013 12:00:00 +0200 <![CDATA[Respective roles of BMP9 and BMP10, the two high affinity ligands of the receptor ALK1, in angiogenesis and lymphangiogenesis]]> sbailly@cea.fr (Sabine BAILLY) Tue, 01 Oct 2013 12:00:00 +0200 <![CDATA[Role of transcription factors of the TGF ß1 signaling network in the control of human keratinocyte stem cell regenerative potential]]> nicolas.fortunel@cea.fr (Nicolas FORTUNEL) <![CDATA[Development of immunological tools for medical imagery and immunotherapy]]> herve.volland@cea.fr (Hervé VOLLAND) Sun, 01 Sep 2013 12:00:00 +0200 <![CDATA[Molecular barcode strategy for screening molecules acting on the prion protein and tumor progression]]> diana.le-roux@cea.fr (Diana LE ROUX) Sun, 01 Sep 2013 12:00:00 +0200 <![CDATA[Study of the prion protein and related proteins as novel therapeutic targets in brain tumors.]]> denis.biard@cea.fr (Denis S.F. BIARD) <![CDATA[Development of a screening methodology for microalgae strains selection based on high quantum yield for biofuel production]]> gatien.fleury@cea.fr (Gatien FLEURY) Tue, 01 Oct 2013 12:00:00 +0200 <![CDATA[Characterization of nanoparticles in biological media and their cellular effects on cells using Atomic Force Microscopy]]> christian.godon@cea.fr (Christian GODON) Tue, 01 Oct 2013 12:00:00 +0200 <![CDATA[Study and optimization of hydrocarbon production by microalgae]]> frederic.beisson@cea.fr (Frédéric BEISSON) Tue, 01 Oct 2013 12:00:00 +0200 <![CDATA[Environmental microbial metagenomes: from NGS analyses to the development of indicators for monitoring]]> scruveil@genoscope.cns.fr (Stéphane CRUVEILLER) Tue, 01 Oct 2013 12:00:00 +0200