Research field
Biochemistry / Life Sciences
Biological chemistry / Life Sciences
Title
Ionising radiation effects on histones
Abstract
We wish to describe the radiation chemistry and biochemistry of histones, in absence or in presence of DNA, and to analyze the impact of the histones post-traductional modifications on their radiosensitivity. We want to locate and to identify damages under radical stress as well as the structural and functional variations. The damages localization will be carried out, amino acid by amino acid, using an original isotopic labelling method.
Location
Institut rayonnement et matière de Saclay
Service Interdisciplinaire sur les Systèmes Moléculaires et les Matériaux
Laboratoire de Radiolyse (LCF)
Centre : Saclay
Starting date : 01/09/2013
Contact person
Jean-Philippe RENAULT
CEA / DSM/IRAMIS/SIS2M/LRad
CEA/Saclay
Bat. 546
91191 Gif/Yvette
Phone : 01 69 08 15 50
University / Graduate School
Paris Sud
Chimie Paris Sud
Thesis supervisor
Serge PIN
CNRS / URA-331
CEA/Saclay
Bat. 546
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